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When bound to the viral DNA elements, occurs atop the ICP4 gene sequence to prevent initiation of transcription from this gene, thereby preventing transcription of other viral genes involved in the lytic cycle.

Coppey J, Sala-Trepat M, Lopez B January 1989.

Itzhaki RF, Lin WR, Shang D, Wilcock GK, Faragher B, Jamieson GA January 1997.

Studies of vulnerable patient populations have indicated that daily use of antivirals such as and valaciclovir can reduce reactivation rates.

Brown JC, Newcomb WW August 2011.

The capsid portal is formed by 12 copies of portal protein, UL6, arranged as a ring; the proteins contain a sequence of , which allow them to adhere to each other.

That means after your first outbreak of sores clears up, you may get another outbreak in the future.

HSV-1 is often acquired orally during childhood.

This research identifies HSVs as the most clearly linked to the establishment of Alzheimer's.