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Derek and Addison's relationship is rocked to the core when a former friend comes to Seattle Grace and his presence promises to shake things up for a few members of the staff.

A lion breaks loose in Seattle, leaving a couple's lives and relationship at risk; Lexie overhears Mark's discussion about moving in with Julia; Teddy begins to take steps towards coming to terms with Henry's death; Callie grills Arizona on her past lovers; and Alex requests to be taken off Morgan's preemie case when she becomes too dependent on him.

Meanwhile, Meredith learns more about her family in fact maybe more than she may have wanted to know through her parents.

Callie is overwhelmed by her new position while Bailey is searching for things to do.

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Meredith last night's stand shows up at the hospital with priapism and they need to call Derek Sheperd for a consult which puts Meredith in a very embarassing position.

Richard endeavors to reunite with his wife, Adele, and decides to retire, only to come home and find his wife with another man.

Cristina spends time with Burke while he recovers.

April and Jackson come to a disagreement on children and religion, and Callie and Arizona try to reconnect in their marriage.